https://xmlpipedb.lmucs.io/biodb/fall2013/index.php?action=history&feed=atom&title=Gleis_Week_11 2026-04-11T03:30:38Z Revision history for this page on the wiki MediaWiki 1.20.3 https://xmlpipedb.lmucs.io/biodb/fall2013/index.php?title=Gleis_Week_11&diff=5409&oldid=prev 2013-11-12T07:00:12Z

<p></p> <table class='diff diff-contentalign-left'> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr style='vertical-align: top;'> <td colspan='2' style="background-color: white; color:black;">← Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 07:00, 12 November 2013</td> </tr><tr><td colspan="2" class="diff-lineno">Line 116:</td> <td colspan="2" class="diff-lineno">Line 116:</td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>#The website is fairly easy to follow although the site navigation is not the most intuitive.&#160; There is a help section with a variety of video tutorials.&#160; The results make sense as long as the desired result is specific.</div></td><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>#The website is fairly easy to follow although the site navigation is not the most intuitive.&#160; There is a help section with a variety of video tutorials.&#160; The results make sense as long as the desired result is specific.</div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>#LmjF.##.####</div></td><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>#LmjF.##.####</div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">===Powerpoint Presentation===</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">[[Media:Leishmania_major_BD.pdf|Leishmania major Genome Reference Article Presentation]]</ins></div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>[[User:Gleis|Gleis]] ([[User talk:Gleis|talk]]) 22:08, 11 November 2013 (PST)</div></td><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>[[User:Gleis|Gleis]] ([[User talk:Gleis|talk]]) 22:08, 11 November 2013 (PST)</div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category:Journal]]</div></td><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category:Journal]]</div></td></tr> </table>

Gleis https://xmlpipedb.lmucs.io/biodb/fall2013/index.php?title=Gleis_Week_11&diff=5392&oldid=prev 2013-11-12T06:08:42Z

<p></p> <table class='diff diff-contentalign-left'> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr style='vertical-align: top;'> <td colspan='2' style="background-color: white; color:black;">← Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 06:08, 12 November 2013</td> </tr><tr><td colspan="2" class="diff-lineno">Line 116:</td> <td colspan="2" class="diff-lineno">Line 116:</td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>#The website is fairly easy to follow although the site navigation is not the most intuitive.&#160; There is a help section with a variety of video tutorials.&#160; The results make sense as long as the desired result is specific.</div></td><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>#The website is fairly easy to follow although the site navigation is not the most intuitive.&#160; There is a help section with a variety of video tutorials.&#160; The results make sense as long as the desired result is specific.</div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>#LmjF.##.####</div></td><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>#LmjF.##.####</div></td></tr> <tr><td class='diff-marker'>−</td><td style="background: #ffa; color:black; font-size: smaller;"><div>22:<del class="diffchange diffchange-inline">07</del>, 11 November 2013 (PST)</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>&#160;</div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">[[User:Gleis|Gleis]] ([[User talk:Gleis|talk]]) </ins>22:<ins class="diffchange diffchange-inline">08</ins>, 11 November 2013 (PST)</div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category:Journal]]</div></td><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category:Journal]]</div></td></tr> </table>

Gleis https://xmlpipedb.lmucs.io/biodb/fall2013/index.php?title=Gleis_Week_11&diff=5390&oldid=prev 2013-11-12T06:07:19Z

<p></p> <table class='diff diff-contentalign-left'> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr style='vertical-align: top;'> <td colspan='2' style="background-color: white; color:black;">← Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 06:07, 12 November 2013</td> </tr><tr><td colspan="2" class="diff-lineno">Line 116:</td> <td colspan="2" class="diff-lineno">Line 116:</td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>#The website is fairly easy to follow although the site navigation is not the most intuitive.&#160; There is a help section with a variety of video tutorials.&#160; The results make sense as long as the desired result is specific.</div></td><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>#The website is fairly easy to follow although the site navigation is not the most intuitive.&#160; There is a help section with a variety of video tutorials.&#160; The results make sense as long as the desired result is specific.</div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>#LmjF.##.####</div></td><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>#LmjF.##.####</div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">22:07, 11 November 2013 (PST)</ins></div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category:Journal]]</div></td><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category:Journal]]</div></td></tr> </table>

Gleis https://xmlpipedb.lmucs.io/biodb/fall2013/index.php?title=Gleis_Week_11&diff=5389&oldid=prev 2013-11-12T06:07:02Z

<p></p> <table class='diff diff-contentalign-left'> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr style='vertical-align: top;'> <td colspan='2' style="background-color: white; color:black;">← Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 06:07, 12 November 2013</td> </tr><tr><td colspan="2" class="diff-lineno">Line 116:</td> <td colspan="2" class="diff-lineno">Line 116:</td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>#The website is fairly easy to follow although the site navigation is not the most intuitive.&#160; There is a help section with a variety of video tutorials.&#160; The results make sense as long as the desired result is specific.</div></td><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>#The website is fairly easy to follow although the site navigation is not the most intuitive.&#160; There is a help section with a variety of video tutorials.&#160; The results make sense as long as the desired result is specific.</div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>#LmjF.##.####</div></td><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>#LmjF.##.####</div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">[[Category:Journal]]</ins></div></td></tr> </table>

Gleis https://xmlpipedb.lmucs.io/biodb/fall2013/index.php?title=Gleis_Week_11&diff=5273&oldid=prev 2013-11-11T08:01:26Z

<p></p> <table class='diff diff-contentalign-left'> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr style='vertical-align: top;'> <td colspan='2' style="background-color: white; color:black;">← Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 08:01, 11 November 2013</td> </tr><tr><td colspan="2" class="diff-lineno">Line 114:</td> <td colspan="2" class="diff-lineno">Line 114:</td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>#There are links to GeneDB as well as EuPathDB. THe website also provides links to a variety of tools contained in other databases.</div></td><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>#There are links to GeneDB as well as EuPathDB. THe website also provides links to a variety of tools contained in other databases.</div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>#Files are available to download in many formats such as .ppt .pdf .docx .tiff .jpg .txt .gff</div></td><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>#Files are available to download in many formats such as .ppt .pdf .docx .tiff .jpg .txt .gff</div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">#The website is fairly easy to follow although the site navigation is not the most intuitive.&#160; There is a help section with a variety of video tutorials.&#160; The results make sense as long as the desired result is specific.</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">#LmjF.##.####</ins></div></td></tr> </table>

Gleis https://xmlpipedb.lmucs.io/biodb/fall2013/index.php?title=Gleis_Week_11&diff=5272&oldid=prev 2013-11-11T07:52:44Z

<p></p> <table class='diff diff-contentalign-left'> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr style='vertical-align: top;'> <td colspan='2' style="background-color: white; color:black;">← Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 07:52, 11 November 2013</td> </tr><tr><td colspan="2" class="diff-lineno">Line 112:</td> <td colspan="2" class="diff-lineno">Line 112:</td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>#Data is provided freely for public use. No restrictions.</div></td><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>#Data is provided freely for public use. No restrictions.</div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>#Last updated 25 September 2013</div></td><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>#Last updated 25 September 2013</div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">#There are links to GeneDB as well as EuPathDB. THe website also provides links to a variety of tools contained in other databases.</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">#Files are available to download in many formats such as .ppt .pdf .docx .tiff .jpg .txt .gff</ins></div></td></tr> </table>

Gleis https://xmlpipedb.lmucs.io/biodb/fall2013/index.php?title=Gleis_Week_11&diff=5271&oldid=prev 2013-11-11T07:47:35Z

<p></p> <table class='diff diff-contentalign-left'> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr style='vertical-align: top;'> <td colspan='2' style="background-color: white; color:black;">← Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 07:47, 11 November 2013</td> </tr><tr><td colspan="2" class="diff-lineno">Line 106:</td> <td colspan="2" class="diff-lineno">Line 106:</td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>*Genomic data provides important insight to drug targets for Leishmanaiasis</div></td><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>*Genomic data provides important insight to drug targets for Leishmanaiasis</div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>===Model Organism Database===</div></td><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>===Model Organism Database===</div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">http://tritrypdb.org/tritrypdb/</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">#Sequence information, functional data and annotations are included in the database; meta-database, curated manually in a community setting</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">#EuPathDB maintains the site.&#160; A special committee of Leishmania experts from a variety of universities&#160; oversees the curation of the TriTrypDB site</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">#Funding is provided by The Bill and Melinda Gates Foundation, Wellcome Trust, and NIAID</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">#Data is provided freely for public use. No restrictions.</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">#Last updated 25 September 2013</ins></div></td></tr> </table>

Gleis https://xmlpipedb.lmucs.io/biodb/fall2013/index.php?title=Gleis_Week_11&diff=5257&oldid=prev 2013-11-11T03:50:30Z

<p></p> <table class='diff diff-contentalign-left'> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr style='vertical-align: top;'> <td colspan='2' style="background-color: white; color:black;">← Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 03:50, 11 November 2013</td> </tr><tr><td colspan="2" class="diff-lineno">Line 105:</td> <td colspan="2" class="diff-lineno">Line 105:</td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>*Leishmania genomes share many similarities but genomic differences express important factors that enable specific functioning of the organism</div></td><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>*Leishmania genomes share many similarities but genomic differences express important factors that enable specific functioning of the organism</div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>*Genomic data provides important insight to drug targets for Leishmanaiasis</div></td><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>*Genomic data provides important insight to drug targets for Leishmanaiasis</div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">===Model Organism Database===</ins></div></td></tr> </table>

Gleis https://xmlpipedb.lmucs.io/biodb/fall2013/index.php?title=Gleis_Week_11&diff=5239&oldid=prev 2013-11-11T01:22:37Z

<p></p> <table class='diff diff-contentalign-left'> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr style='vertical-align: top;'> <td colspan='2' style="background-color: white; color:black;">← Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 01:22, 11 November 2013</td> </tr><tr><td colspan="2" class="diff-lineno">Line 91:</td> <td colspan="2" class="diff-lineno">Line 91:</td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>*This is not produced in mammals and is therefore and excellent drug target</div></td><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>*This is not produced in mammals and is therefore and excellent drug target</div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>*The major insect stage surface protein of Leishmania is GP63 which is a zinc metallopeptidase</div></td><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>*The major insect stage surface protein of Leishmania is GP63 which is a zinc metallopeptidase</div></td></tr> <tr><td class='diff-marker'>−</td><td style="background: #ffa; color:black; font-size: smaller;"><div>*</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>*<ins class="diffchange diffchange-inline">Surface proteins appear to be expressed variably with development</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">*L. major shares surface molecule similarity to other related species</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">===X. Proteolysis===</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">*Peptidases are very diverse and are characterized by evolutionary similarity</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">*L. major lacks certain peptidases common to other parasites but share similarities to other Leishmania species</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">*Exhibit nonlysosomal protein degradation through ubiquitin</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">*Cell death through caspase independent mechanism</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">*No trypsin/chymotripsin</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">*Other serene peptidases present as well as other metallopeptidases other than GP63</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">*Lack certain peptidase inhibitors but exhibit inhibitors not present in mammals</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">*Produce inhibitors of peptidases to aid in infection of host</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">===XI. Conclusion===</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">*Leishmania genomes share many similarities but genomic differences express important factors that enable specific functioning of the organism</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">*Genomic data provides important insight to drug targets for Leishmanaiasis</ins></div></td></tr> </table>

Gleis https://xmlpipedb.lmucs.io/biodb/fall2013/index.php?title=Gleis_Week_11&diff=5234&oldid=prev 2013-11-11T01:07:33Z

<p></p> <table class='diff diff-contentalign-left'> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr style='vertical-align: top;'> <td colspan='2' style="background-color: white; color:black;">← Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 01:07, 11 November 2013</td> </tr><tr><td colspan="2" class="diff-lineno">Line 84:</td> <td colspan="2" class="diff-lineno">Line 84:</td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>===IX. Surface Molecules===</div></td><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>===IX. Surface Molecules===</div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>*Surface molecules are particularly important for Leishmania due to infectious processes requiring these molecules</div></td><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>*Surface molecules are particularly important for Leishmania due to infectious processes requiring these molecules</div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">*Many genes encoding for these surface molecules appear to be novel and have not been completely identified</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">*Some of these molecules are assembled in the lumen of the golgi due to a need for sugar assembly</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">*L. major specific genes have been identified for these processes</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">*Some of these genes are clustered together on the genome</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">*The primary sphingolipid in Leishmania is IPC</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">*This is not produced in mammals and is therefore and excellent drug target</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">*The major insect stage surface protein of Leishmania is GP63 which is a zinc metallopeptidase</ins></div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>*</div></td><td class='diff-marker'>&#160;</td><td style="background: #eee; color:black; font-size: smaller;"><div>*</div></td></tr> </table>

Gleis