https://xmlpipedb.lmucs.io/biodb/fall2013/index.php?action=history&feed=atom&title=Ksherbina_Week_5Ksherbina Week 5 - Revision history2026-06-02T22:58:10ZRevision history for this page on the wikiMediaWiki 1.20.3https://xmlpipedb.lmucs.io/biodb/fall2013/index.php?title=Ksherbina_Week_5&diff=2344&oldid=prevKsherbina: Answered reflection questions.2013-09-27T06:19:58Z<p>Answered reflection questions.</p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The human epidermal growth factor receptor (EGFR) is a transmembrane protein and a type of tyrosine kinase, which transfers a phosphate from ATP to the amino acid tyrosine in another protein. This phosphorylation initiates numerous downstream signaling pathways. It is also capable of forming homodimers and heterodimers, which lead to its autophosphorylation allowing it to interact with other proteins. The human EGFR protein is found in different tissues and in different types of membranes, such as that of the cell, the Golgi apparatus, endoplasmic reticulum, and endosome. It is linked to both lung and ovarian cancer.   </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The human epidermal growth factor receptor (EGFR) is a transmembrane protein and a type of tyrosine kinase, which transfers a phosphate from ATP to the amino acid tyrosine in another protein. This phosphorylation initiates numerous downstream signaling pathways. It is also capable of forming homodimers and heterodimers, which lead to its autophosphorylation allowing it to interact with other proteins. The human EGFR protein is found in different tissues and in different types of membranes, such as that of the cell, the Golgi apparatus, endoplasmic reticulum, and endosome. It is linked to both lung and ovarian cancer.   </div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">==Answer to Reflection Questions==</ins></div></td></tr>
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<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">#The purpose of this exercise was to become familiar with the UniProt database by exploring the different kinds of information it provides about the structure and function of the Human EGFR protein.</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">#Through this exercise, I learned how to connect genomic, transcriptomic, and proteomic information regarding a protein of interest by navigating between different types of databases.  </ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">#I had some difficulty understanding what was the function of some of the syntax of the RDF/XML file. </ins></div></td></tr>
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</table>Ksherbinahttps://xmlpipedb.lmucs.io/biodb/fall2013/index.php?title=Ksherbina_Week_5&diff=2338&oldid=prevKsherbina: /* Summary of Information on the Human EGFR Protein */ Edited summary of the protein.2013-09-27T06:04:25Z<p><span dir="auto"><span class="autocomment">Summary of Information on the Human EGFR Protein: </span> Edited summary of the protein.</span></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>===Summary of Information on the Human EGFR Protein===</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>===Summary of Information on the Human EGFR Protein===</div></td></tr>
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<tr><td class='diff-marker'>−</td><td style="background: #ffa; color:black; font-size: smaller;"><div>The human epidermal growth factor receptor (EGFR) is a transmembrane protein and a type of tyrosine kinase, which transfers a phosphate from ATP to the tyrosine in another protein. This phosphorylation initiates numerous downstream signaling pathways. It is also capable of forming homodimers and heterodimers, which lead to its autophosphorylation allowing it to interact with other proteins. The human EGFR protein is found in different tissues and in different types of membranes, such as that of the cell, the Golgi apparatus, endoplasmic reticulum, and endosome. It is linked to lung and ovarian cancer<del class="diffchange diffchange-inline">, the latter which expresses isoform 2 of the protein</del>.   </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>The human epidermal growth factor receptor (EGFR) is a transmembrane protein and a type of tyrosine kinase, which transfers a phosphate from ATP to the <ins class="diffchange diffchange-inline">amino acid </ins>tyrosine in another protein. This phosphorylation initiates numerous downstream signaling pathways. It is also capable of forming homodimers and heterodimers, which lead to its autophosphorylation allowing it to interact with other proteins. The human EGFR protein is found in different tissues and in different types of membranes, such as that of the cell, the Golgi apparatus, endoplasmic reticulum, and endosome. It is linked to <ins class="diffchange diffchange-inline">both </ins>lung and ovarian cancer.   </div></td></tr>
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</table>Ksherbina
===Summary of Information on the Human EGFR Protein===
===Summary of Information on the Human EGFR Protein===