Difference between revisions of "Gleis Week 11"
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'''filarial''':related to or infested with or transmitting parasitic worms especially filaria | '''filarial''':related to or infested with or transmitting parasitic worms especially filaria | ||
http://wordnetweb.princeton.edu/perl/webwn?s=filarial | http://wordnetweb.princeton.edu/perl/webwn?s=filarial | ||
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'''trypanosomatid''':common name for a member of the family Trypanosomatidae | '''trypanosomatid''':common name for a member of the family Trypanosomatidae | ||
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'''bromodomain''':Protein containing at least one bromodomain. The bromodomain is a conserved region, approximately 70 amino acids, characteristic for a class of regulatory proteins. It mediates interactions with proteins that are necessary for transcriptional activation. | '''bromodomain''':Protein containing at least one bromodomain. The bromodomain is a conserved region, approximately 70 amino acids, characteristic for a class of regulatory proteins. It mediates interactions with proteins that are necessary for transcriptional activation. | ||
http://www.uniprot.org/keywords/KW-0103 | http://www.uniprot.org/keywords/KW-0103 | ||
| + | ==Reference Article Outline== | ||
| + | ===I. Abstract=== | ||
| + | *Leishmania major causes leishmaniasis, a dreadful human disease found throughout the world. | ||
| + | *Many genes currently studied involved the pathogenic nature of Leishmania major | ||
| + | *The lack of certain genes in the genome of Leishmania suggest novel expression and regulation systems | ||
| + | ===II. Introduction=== | ||
| + | *Leishmania parasites are transmitted by sand flies | ||
| + | *Once Leishmania have infected the host, the parasite subsequently proliferates and spreads throughout the host. | ||
| + | *Different Leishmania species exhibit differences in genome composition and structure | ||
| + | *This article presents the structure and content of the Leishmania major genome | ||
| + | *Special emphasis is given to fundamental molecular processes and pathogen-speicific functions | ||
| + | ===III. Genome structure and content=== | ||
| + | *Shotgun sequencing was used to sequence the genome chromosome by chromosome | ||
| + | * | ||
Revision as of 01:32, 10 November 2013
Contents |
GO Terms
Metacyclic: produced in an intermediate host, and infective for the definitive host; said of the infective stages of trypanosomes. http://medical-dictionary.thefreedictionary.com/metacyclic
Promastigote:The flagellate stage of a trypanosomatid protozoan, as that of any of the Leishmania parasites http://medical-dictionary.thefreedictionary.com/promastigote
Phagolysosome:a cytoplasmic body formed by the fusion of a phagosome, or ingested particle, with a lysosome containing hydrolytic enzymes. The enzymes digest most of the material within the phagosome http://medical-dictionary.thefreedictionary.com/phagolysosome
Tripartite:having three corresponding parts or copies http://www.merriam-webster.com/dictionary/tripartite
"Repeated-repeat": repeated tandem repeats, Copies of DNA sequences which lie adjacent to each other in the same orientation (direct tandem repeats) or in the opposite direction to each other http://www.nlm.nih.gov/cgi/mesh/2011/MB_cgi?mode=&term=Tandem+Repeat
bacterial clade:Related organisms descended from a common ancestor. For example, isolate M of HIV-1 (the human immunodeficiency virus) consists of at least ten clades. Imported from the Greek, klados, branch in 1911 in reference to the Tree of Life. http://www.medterms.com/script/main/art.asp?articlekey=22233
filarial:related to or infested with or transmitting parasitic worms especially filaria http://wordnetweb.princeton.edu/perl/webwn?s=filarial
trypanosomatid:common name for a member of the family Trypanosomatidae http://medical-dictionary.thefreedictionary.com/trypanosomatid
chromodomain:Chromodomains are highly conserved sequence motifs that have been identified in a variety of animal and plant species. A chromodomain harbours a methylated lysine residue. http://www.springerreference.com/docs/html/chapterdbid/34668.html
bromodomain:Protein containing at least one bromodomain. The bromodomain is a conserved region, approximately 70 amino acids, characteristic for a class of regulatory proteins. It mediates interactions with proteins that are necessary for transcriptional activation. http://www.uniprot.org/keywords/KW-0103
Reference Article Outline
I. Abstract
- Leishmania major causes leishmaniasis, a dreadful human disease found throughout the world.
- Many genes currently studied involved the pathogenic nature of Leishmania major
- The lack of certain genes in the genome of Leishmania suggest novel expression and regulation systems
II. Introduction
- Leishmania parasites are transmitted by sand flies
- Once Leishmania have infected the host, the parasite subsequently proliferates and spreads throughout the host.
- Different Leishmania species exhibit differences in genome composition and structure
- This article presents the structure and content of the Leishmania major genome
- Special emphasis is given to fundamental molecular processes and pathogen-speicific functions
III. Genome structure and content
- Shotgun sequencing was used to sequence the genome chromosome by chromosome
