Difference between revisions of "Dwilliams Week 11 assignment"

Revision as of 06:01, 12 November 2013

Article for Journal Club

Stephens, R.S., Kalman, S., Lammel, C., Fan, J., Marathe, R., Aravind, L., Mitchell, W., Olinger, L., Tatusov, R., Zhao, Q., Koonin, E. V., Davis, R.W. (1998) Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis. Science 282: 754-759. doi: 10.1126/science.282.5389.754

Spirochetes -- A microscopic bacterial organism, a spirochete apperars worm-like, spiral-shaped, and wiggles vigorously when viewed under a microscope. Treponema pallidum, the cause of syphilis, is a particularly well-known member of the spirochaeta family. The term spirochete is an odd hybrid of greek and latin roots, the latin spira for coil and the greek chaite for long flowing hair, formed because the spirochete looked like a coil of hair.

Porphyrin -- porphyrins are pigments found in both animal and plant life. They are all chelates with metals (fe, mg, co, zn, cu, ni) and constituents of haemoglobin, chlorophyll, cytochromes. <http://www.biology-online.org/dictionary/Porphyrin> Accessed 10 November, 2013
pseudouridylate synthase activity -- Catalysis of the reaction: D-ribose 5-phosphate + uracil = H(2)O + pseudouridine 5'-phosphate.

Elementary body -- "Miyagawa bodies" A term previously used to refer to chlamydia trachomatis (miyagawanella lymphogranulomatosis), the elementary body's that develop in the intracytoplasmic microcolonies of lymphogranuloma venereum.

Reticulate body -- The chlamydia have two forms, transforming into the reproductive reticulate body after being endocytosed by a host cell.

(2) A part of protein that can fold, function and exist independently of the rest of the protein chain or structure. <http://www.biology-online.org/dictionary/Protein_domain>

Mycobacteria -- bacteria with unusual cell walls that are resistant to digestion, being waxy, very hydrophobic and rich in lipid, especially esterified mycolic acids. Staining properties differ from those of gram-negative and gram-positive organisms, being acid-fast. Many are intracellular parasites, causing serious diseases such as leprosy and tuberculosis. Cell wall has strong immunostimulating (adjuvant) properties due to muramyl dipeptide (MDP). Mycobacterium bovis causes tuberculosis in cattle, attenuated strain is bacille Calmette-Guerin (bCG), used for immunisation. Mycobacterium leprae is the causative agent of leprosy. Mycobacterium microti is a mycobacterium that causes tuberculosis like disease in small rodents (Microtus microtus is the vole), will infect mice but not humans and is therefore much used as a laboratory model. Releases large amounts of cAMP which may inhibit lysosome phagosome fusion. Mycobacterium tuberculosis Is an obligate anaerobic nonmotile bacterium, causative agent of tuberculosis in humans. Lives intracellularly in macrophages.

@@ Line 1: / Line 1: @@
 '''Article for Journal Club'''
 *:Stephens, R.S., Kalman, S., Lammel, C., Fan, J., Marathe, R., Aravind, L., Mitchell, W., Olinger, L., Tatusov, R., Zhao, Q., Koonin, E. V., Davis, R.W. (1998) [http://www.sciencemag.org/content/282/5389/754.long Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis.] Science 282: 754-759. doi: 10.1126/science.282.5389.754
 ==10 Biological Terms from Article==
 *Spirochetes -- A microscopic bacterial organism, a spirochete apperars worm-like, spiral-shaped, and wiggles vigorously when viewed under a microscope. Treponema pallidum, the cause of syphilis, is a particularly well-known member of the spirochaeta family. The term spirochete is an odd hybrid of greek and latin roots, the latin spira for coil and the greek chaite for long flowing hair, formed because the spirochete looked like a coil of hair.
 <http://www.biology-online.org/dictionary/Spirochetes> Accessed 10 November, 2013