Spliceosome Database

1. I accessed the Spliceosome Database Spliceosome Database
2. The purpose of this database is to unify and simplify the many (over 200) proteins that spliceosomes are assembled from. The large variety of names and identifiers present in the literature was the inspiration for this database.
3. The database contains the names, orthologs, and gene identifiers of spliceosome proteins, links to gene and protein records for the components of spliceosomes found in other databases, and "tools to compare the association of spliceosome proteins with complexes that form at specific stages of spliceosome assembly based on a compendium of mass spectrometry experiments that identified proteins in purified splicing complexes" (Cvitkovic & Jurica, 2013).
4. The species covered by the database are Homo sapiens (humans), Schizosaccharomyces cerevisiae (yeast), Schizosaccharomyces pombe (yeast), Drosophila melanogaster (fruit fly), Caenorhabditis elegans (nematode), Plasmodium falciparum (malaria causing protozoa), Gallus gallus (chicken), Trypanosoma brucei (trypanosome), Leishmania major (protozoa), and Arabidopsis thaliana (small flowering plant).
5. This database can answer the biological questions "What genes code for spliceosome proteins and RNAs?", "What proteins are involved in the formation of spliceosomes?", and "How do spliceosomes differ across species?".
6. This database is a specialty database that focuses on the genes, proteins, protein conformations, and small nuclear RNAs (snRNA) that are found in spliceosomes in humans and several model organisms listed above in #4.
7. Ivan Cvitkovic and Melissa S. Jurica maintain the database, though the paper and database website list only Melissa S. Jurica as the contact person and recipient of the NIH grant.
8. The National Institute of Health provides funding for this database.
9. The Spliceosome Database is free and available to the public.