Revision as of 06:47, 12 October 2015

The FDA Drug Database

Electronic Lab Notebook

Application.txt --> SQL commands

   cat application.txt | sed "s/\t/~/g" | sed -r "s/( ){2}//g" | sed "s/ \~/~/g" | sed "s/\~ /~/g" | 
   sed "s/\~\~/~null~/g" | sed "s/\~\~/~null~/g" | sed "s/\~\r$/~null/g" | sed "s/~/,'/1" | sed "s/~/','/1" | sed "s/~/',/1" | 
   sed "s/~/,/1" | sed "s/~/,'/1" | sed "s/~/',/1" | sed "s/~/,'/1" | sed "s/~/','/1" |sed "s/~/,'/1" | sed "s/\r$/'/g" | 
   sed "s/'null'/null/g" | sed "s/'null/null/g" | sed "s/^/insert into application(ApplNo,ApplType,SponsorApplicant,
   MostRecentLabelAvailableFlag,CurrentPatentFlag,ActionType,Chemical_Type,Ther_Potential,Orphan_Code) values(/g" | 
   sed "s/$/);/g" | sed 1D > ~/public_html/application.sql.txt

Product.txt --> SQL commands

   cat Product.txt | sed "s/\*\*Federal Register determination that product was not discontinued or withdrawn for safety or 
   efficacy reasons\*\*//g" | sed "s/\*\*Federal Register determination that product was not discontinued or withdrawn for safety or 
   efficacy\*\*//g" | sed "s/\*\*Federal Register notice determination that product was not discontinued or withdrawn for safety or 
   efficacy reasons\*\*//g" | sed "s/\*\*Federal Registration determination that product was not discontinued or withdrawn for safety 
   or efficacy reasons\*\*//g" | sed "s/See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium//g" | 
   sed "s/'//g" | sed "s/\t/*/g" | sed -r "s/( ){2}//g" | sed "s/ \*/*/g" | sed "s/\* /*/g" | sed "s/\*\*/*null*/g" | 
   sed "s/\*\*/*null*/g" | sed "s/\*/,/1" | sed "s/\*/,'/1" | sed "s/\*/','/1" | sed "s/\*/',/1" | sed "s/\*/,'/1" | sed "s/\*/',/1" | 
   sed "s/\*/,'/1" | sed "s/\*/','/1" | sed "s/\r$/'/g" | sed "s/^/insert into product(ApplNo,ProductNo,Form,Dosage,ProductMktStatus,
   TECode,ReferenceDrug,drugname,activeingred) values(/g" | sed "s/$/);/g" | sed 1D > ~/public_html/Product.sql.txt

Questions to Answer

1. Provide the DDL (create table) statements that you used for your application and product tables.
   • For application.txt
     • create table application (ApplNo int primary key, ApplType varchar, SponsorApplicant varchar, MostRecentLabelAvailableFlag boolean, CurrentPatentFlag boolean, ActionType varchar, Chemical_Type int, Ther_Potential varchar, Orphan_Code varchar)
   • For product.txt
     • create table Product (ApplNo int, ProductNo int, Form varchar, Dosage varchar, ProductMktStatus varchar, TECode varchar, ReferenceDrug int, drugname varchar, activeingred varchar)
2. Provide the sed command sequences that you used to convert the raw text files into sequences of SQL insert statements.
   • For application.txt
     • cat application.txt | sed "s/\t/~/g" | sed -r "s/( ){2}//g" | sed "s/ \~/~/g" | sed "s/\~ /~/g" | sed "s/\~\~/~null~/g" | sed "s/\~\~/~null~/g" | sed "s/\~\r$/~null/g" | sed "s/~/,'/1" | sed "s/~/','/1" | sed "s/~/',/1" | sed "s/~/,/1" | sed "s/~/,'/1" | sed "s/~/',/1" | sed "s/~/,'/1" | sed "s/~/','/1" |sed "s/~/,'/1" | sed "s/\r$/'/g" | sed "s/'null'/null/g" | sed "s/'null/null/g" | sed "s/^/insert into application(ApplNo,ApplType,SponsorApplicant,MostRecentLabelAvailableFlag,CurrentPatentFlag,ActionType,Chemical_Type,Ther_Potential,Orphan_Code) values(/g" | sed "s/$/);/g" | sed 1D > ~/public_html/application.sql.txt
   • For product.txt
     • cat Product.txt | sed "s/\*\*Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons\*\*//g" | sed "s/\*\*Federal Register determination that product was not discontinued or withdrawn for safety or efficacy\*\*//g" | sed "s/\*\*Federal Register notice determination that product was not discontinued or withdrawn for safety or efficacy reasons\*\*//g" | sed "s/\*\*Federal Registration determination that product was not discontinued or withdrawn for safety or efficacy reasons\*\*//g" | sed "s/See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium//g" | sed "s/'//g" | sed "s/\t/*/g" | sed -r "s/( ){2}//g" | sed "s/ \*/*/g" | sed "s/\* /*/g" | sed "s/\*\*/*null*/g" | sed "s/\*\*/*null*/g" | sed "s/\*/,/1" | sed "s/\*/,'/1" | sed "s/\*/','/1" | sed "s/\*/',/1" | sed "s/\*/,'/1" | sed "s/\*/',/1" | sed "s/\*/,'/1" | sed "s/\*/','/1" | sed "s/\r$/'/g" | sed "s/^/insert into product(ApplNo,ProductNo,Form,Dosage,ProductMktStatus,TECode,ReferenceDrug,drugname,activeingred) values(/g" | sed "s/$/);/g" | sed 1D > ~/public_html/Product.sql.txt
3. Using the command line, how can you determine the number of records in each file? Provide the command.
   • For application.txt
     • wc application.txt
   • For product.txt
     • wc Product.txt
   • Then subtract 1 from the first number listed in both cases(since it represents the number of lines, and the first line consists of column headings while all other lines are records).
4. Using SQL, how can you determine the number of records in the table corresponding to the file? Provide the SQL select statement.
   • For application.txt
     • select * from application
   • For product.txt
     • select * from product
5. In your database, are these numbers the same or different? Explain why you think so.
   • After subtracting the line that contains the column from the command line answer, the numbers are the same.

   For the remaining questions, supply (a) the answer to the question and (b) the SQL statement that you used to answer the question.

6. What are the names of the drug products that are administered in the form INJECTABLE;INTRAVENOUS, SUBCUTANEOUS?
7. What are the names of the drug products whose active ingredient (activeingred) is ATROPINE?
8. In what forms and dosages can the drug product named BENADRYL be administered?
9. Which drug products have a name ending in ESTROL?
10. Produce a table listing all of the known values for the therapeutic_potential column in the application table and how many application records there are of each. (Side note: The therapeutic_potential codes are explained in the ReviewClass_Lookup.txt file, in case you’re interested.)
11. Produce a table listing all of the known values for the chemical_type column in the application table and how many application records there are of each. (Side note: The chemical_type codes are explained in the ChemTypeLookup.txt file, in case you’re interested.)
12. What are the names of the drug products that are sponsored (sponsor applicant column) by MERCK?
13. Which sponsor applicant companies have the text LABS in their names and have products whose active ingredients (activeingred) include both ASPIRIN and CAFFEINE?