*What criteria did Merrell et al. (2002) use to determine a significant gene expression change? How does it compare to our method? '''Merrell et al. (2002) used a “two-class SAM analysis” with the determination of significance based on the level of expression which must have been at least a twofold change. Merrell et al. (2002) looked at the actual change in expression to figure out what was significant while I used the p value, which is the probability that changes in expression were due to chance. Merrel et al. (2002) used a more stringent method because they found 237 genes that were significantly changed while we found 918 using the criteria: -0.25 < pvalue >0 .25.'''

*What criteria did Merrell et al. (2002) use to determine a significant gene expression change? How does it compare to our method? '''Merrell et al. (2002) used a “two-class SAM analysis” with the determination of significance based on the level of expression which must have been at least a twofold change. Merrell et al. (2002) looked at the actual change in expression to figure out what was significant while I used the p value, which is the probability that changes in expression were due to chance. Merrel et al. (2002) used a more stringent method because they found 237 genes that were significantly changed while we found 918 using the criteria: -0.25 < pvalue >0 .25.'''