|
|
| **Suggests that the ''Bordetella'' variable host specificity may be influenced by changes in this receptor-ligand interaction. | | **Suggests that the ''Bordetella'' variable host specificity may be influenced by changes in this receptor-ligand interaction. |
| *Autotransporter protein variation. | | *Autotransporter protein variation. |
− | **Table 2 demonstrate differing autotransporter complements amongst the three species. | + | **'''Table 2''' lists the autotransporter proteins encoded for by ''B. pertussis'', ''B. parapertussis'', and ''B. bronchiseptica''. This table demonstrates that autotransporter complements differ amongst the three species. |
| ** ''B. pertussis'' and ''B. parapertussis'' have fewer genes and more pseudogenes. | | ** ''B. pertussis'' and ''B. parapertussis'' have fewer genes and more pseudogenes. |
| **May also impact host specificity. | | **May also impact host specificity. |
| *Siderophore similarities and variation. | | *Siderophore similarities and variation. |
| **All three species contain operons for the siderophore alcaligin, suggesting they scavenge iron from their hosts. | | **All three species contain operons for the siderophore alcaligin, suggesting they scavenge iron from their hosts. |
| + | **'''Table 3''' lists the TonB-dependent ferric complex receptors encoded for by ''B. pertussis'', ''B. parapertussis'', and ''B. bronchiseptica''. This table demonstrates that each species codes for up to 16 of these molecules, which also suggests iron scavenging behavior. |
| ** ''B. pertussis'' and ''B. parapertussis'' have fewer genes and more pseudogenes that code for siderophores. | | ** ''B. pertussis'' and ''B. parapertussis'' have fewer genes and more pseudogenes that code for siderophores. |
| **Lacking necessary siderophores may influence host specificity. | | **Lacking necessary siderophores may influence host specificity. |
|
|
| **Synonymous substitution frequency values were calculated from orthologous gene pairs. | | **Synonymous substitution frequency values were calculated from orthologous gene pairs. |
| **Ages of divergence were estimated. | | **Ages of divergence were estimated. |
| + | |
| + | ====Preliminary Presentation==== |
| + | File Link: [[File:Genomepaper cw20151116.pdf]] |
| | | |
| ==''Bordetella Pertussis'' Model Organism Database== | | ==''Bordetella Pertussis'' Model Organism Database== |
− | ===Identifying the ''Bordetella Pertussis''=== | + | ===Identifying the ''Bordetella Pertussis'' MOD=== |
| On Thursday, November 12, several ''Google'' searches were conducted to find a potential MOD for ''Bordetella Pertussis''. The following queries returned unsuccessful results: | | On Thursday, November 12, several ''Google'' searches were conducted to find a potential MOD for ''Bordetella Pertussis''. The following queries returned unsuccessful results: |
| *"Bordetella Pertussis Model Organism Database"- too narrow of a search for this organism. | | *"Bordetella Pertussis Model Organism Database"- too narrow of a search for this organism. |
|
|
| #**This also suggested that I had found the MOD. | | #**This also suggested that I had found the MOD. |
| #I confirmed the GeneDB website as the ''Bordetella pertussis'' MOD with Dr. Dahlquist. | | #I confirmed the GeneDB website as the ''Bordetella pertussis'' MOD with Dr. Dahlquist. |
− | ===Assessing the Gene DB MOD for ''Bordetella pertussis''=== | + | ===Assessing the GeneDB MOD for ''Bordetella pertussis''=== |
| + | '''Citation for GeneDB:''' |
| + | *'''Logan-Klumpler, F. J., De Silva, N., Boehme, U., et al. (2012). GeneDB—an annotation database for pathogens. Nucleic acids research, 40(D1), D98-D108. doi: 10.1093/nar/gkr1032''' |
| # What types of data can be found in the database (sequence, structures, annotations, etc.); is it a primary or “meta” database; is it curated electronically, manually [in-house], or manually [community])? | | # What types of data can be found in the database (sequence, structures, annotations, etc.); is it a primary or “meta” database; is it curated electronically, manually [in-house], or manually [community])? |
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