Eyanosch Week 4

Human genes

about 50% repeated bp's

about 5% code for proteins

45% are regulatory (differentiation)

3 million bp's = human genome size

Roughly ~ 20,296 genes (protein coding genes)

humans have about 100,000 different proteins in our cells

Open reading frame and doing translation = area coded for a certain gene

Bioinformatics

Database analytical tools - available access to lots of data

• information

• • representation, organization, manipulation, distribution, maintenance

transcends all science, interdisciplinary

check out Data life cycle (plan, collect, assure, describe, preserver, discover, integrate, analyze)

• Key Concepts

• • ID's = identifiers
  • Record = entry in a database
  • searching a database is executing a query
  • Different databases use different file formats

Pertinent types for this class -Sequence -3d structure -Model organism databases -etc.

Major databases to note

1. NCBI: National Center for Biotechnology Information
   • GenBank
   • Gene
   • Pubmed
2. uniprot (formerly SWISS-PROT