Aporras1 Week 4

User Page: Antonio Porras

Assignment Page: Week 4

Electronic Notebook

1. I visited the SGD Database and we chose the CLN1 gene as the model organism.
2. First, searched through information on the SGD database and found the following:
   • Overview: regulation of cell cycle promoting first growth phase to S phase.
   • Found on chromosome XIII; also provides the sequence.
   • Cyclin dependent protein kinase.
   • Found within the nucleus and the cytoplasm.
   • Encodes for a G1 cyclin which regulates the cell cycle.
   • Cyclins are essential because they activate CDKs at the correct times within the cell cycle.
   • Provides length of protein to be 546 a.a., PI to be 5.62, and molecular weight to be 62038.2
   • ANother observation on the website, it provides additional literature regarding the study of CLN1.
3. I then searched on the NCBI Gene Database and gathered what I thought to be relevant information:
   • A protein coding gene also known as YMR199W
   • The genomic sequence is NC_001145.3
   • Provides various interactions with other genes, however this list is extensive/exhaustive and not essential to understand the function of the gene.