Difference between revisions of "Gleis Week 5"
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==E-Notebook== | ==E-Notebook== | ||
:*Obtained copy of Bioinformatics for Dummies Chapter 4 | :*Obtained copy of Bioinformatics for Dummies Chapter 4 | ||
| + | :*Read the introduction to Uniprot | ||
| + | :*Searched for "P00533" in the query of uniprot.org | ||
| + | :*Read the rest of the chapter examining each feature outlined in the chapter | ||
| + | :*For the outdated portions of the Chapter I referenced [[Week 5]] which explained some of the changes | ||
| + | ==Summary== | ||
| + | The EGFR is a human receptor tyrosine kinase meaning its catalytic activity is derived from the phosphorylation of a tyrosine. The binding of an appropriate ligand to the protein causes a signal cascade within the cell. EGFR is a membrane spanning protein which enables the protein to bind ligands outside of the membrane and catalyze reactions within the membrane. EGFR is a known oncogene and is believed to play a role in the development of non-small cell lung cancer. One of the expressed domains in EGFR is a membrane helix. The protein is found in tissues throughout the body and plays a role in a large number of cellular processes. | ||
| + | ==Questions== | ||
| + | #The purpose of this exercise was to gain familiarity with the uniprot program while simultaneously concentrating on developing good lab notebook skills. | ||
| + | #From this exercise I learned that I am not very careful with keeping records of my work. Working with UniProt I learned that there is a wealth of information of proteins at Uniprot, even information regarding disease. | ||
| + | #There is such a wealth of information on the site that I have not yet mastered the skills to find the information I am looking for. Additionally I have little knowledge of working with the dozens of tools at the researchers disposal on Uniprot. | ||
| + | |||
| + | [[User:Gleis|Gleis]] ([[User talk:Gleis|talk]]) 17:18, 9 October 2013 (PDT) | ||
| + | [[Category:Journal Entry]] | ||
Latest revision as of 00:18, 10 October 2013
[edit] E-Notebook
- Obtained copy of Bioinformatics for Dummies Chapter 4
- Read the introduction to Uniprot
- Searched for "P00533" in the query of uniprot.org
- Read the rest of the chapter examining each feature outlined in the chapter
- For the outdated portions of the Chapter I referenced Week 5 which explained some of the changes
[edit] Summary
The EGFR is a human receptor tyrosine kinase meaning its catalytic activity is derived from the phosphorylation of a tyrosine. The binding of an appropriate ligand to the protein causes a signal cascade within the cell. EGFR is a membrane spanning protein which enables the protein to bind ligands outside of the membrane and catalyze reactions within the membrane. EGFR is a known oncogene and is believed to play a role in the development of non-small cell lung cancer. One of the expressed domains in EGFR is a membrane helix. The protein is found in tissues throughout the body and plays a role in a large number of cellular processes.
[edit] Questions
- The purpose of this exercise was to gain familiarity with the uniprot program while simultaneously concentrating on developing good lab notebook skills.
- From this exercise I learned that I am not very careful with keeping records of my work. Working with UniProt I learned that there is a wealth of information of proteins at Uniprot, even information regarding disease.
- There is such a wealth of information on the site that I have not yet mastered the skills to find the information I am looking for. Additionally I have little knowledge of working with the dozens of tools at the researchers disposal on Uniprot.
