SIR2 Week 3

Here is some info about SIR2 from the page

NAD-dependent histone deacetylase involved in chromatin assembly, organization and silencing. Also involved in sister chromatid cohesion, double-strand break repair, and the tethering of telomeres at the nuclear periphery. Source: ? one of the ones from class

   Conserved NAD+ dependent histone deacetylase of the Sirtuin family; deacetylation targets are primarily nuclear proteins; required for telomere hypercluster formation in quiescent yeast cells; involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and rDNA; negatively regulates initiation of DNA replication; functions as regulator of autophagy like mammalian homolog SIRT1, and also of mitophagy [Source:SGD;Acc:S000002200]