SIR2 Week 3

Here is some info about SIR2 from the page

NAD-dependent histone deacetylase involved in chromatin assembly, organization and silencing. Also involved in sister chromatid cohesion, double-strand break repair, and the tethering of telomeres at the nuclear periphery. Source: ? one of the ones from class

   Conserved NAD+ dependent histone deacetylase of the Sirtuin family; deacetylation targets are primarily nuclear proteins; required for telomere hypercluster formation in quiescent yeast cells; involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and rDNA; negatively regulates initiation of DNA replication; functions as regulator of autophagy like mammalian homolog SIRT1, and also of mitophagy [Source:SGD;Acc:S000002200]

Summary:

Sir 2 is a member of the Sirtuin family. Sir2 is crucial for cellular function, as it deacetylates nuclear proteins, facilitating telomere formation during cell dormancy and regulating lifespan. It also silences genes at specific chromosomal sites and suppresses early DNA replication, contributing to genome stability. Similar to its mammalian counterpart SIRT1, it regulates autophagy and mitophagy, promoting cellular health. Additionally, it influences chromatin structure through histone deacetylase activity and participates in processes like protein complex localization and metabolic regulation. Found in various cellular regions, including chromosomes and nucleoli, it's part of the RENT complex. Interestingly, it's associated with diseases like Alzheimer's, Parkinson's, diabetes mellitus, and Huntington's disease in humans, with SIRT1 being its counterpart present in humans.

Charlotte's WIP Section

Edit here so we don't overwrite each other