Difference between revisions of "Vkuehn Week 11"
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*#Outcome of infection depends on species, host immune system and host genetics | *#Outcome of infection depends on species, host immune system and host genetics | ||
*Interesting to look at genome because of the unique mechanism of regulating transcription which is atypical for eukaryotes | *Interesting to look at genome because of the unique mechanism of regulating transcription which is atypical for eukaryotes | ||
| + | *:Leishmania major is considered an "Old World Leishmania" species, meaning it contains 36 chromosome pairs. There are approximately 30 Leishmania species who's gene order is highly conserved. | ||
*:Ways in which it differs: | *:Ways in which it differs: | ||
*:#Organization of protein coding genes: long, strand-specific polycistronic clusters | *:#Organization of protein coding genes: long, strand-specific polycistronic clusters | ||
Revision as of 03:29, 10 November 2013
Journal Club Preparation: Leishmania Major
Genome Reference Paper: The Genome of the Kinetoplastid Parasite, Leishmania major (Reference Genome)
10 Biological Terms
Article Outline
Introduction
- It is important to study the genome of Leishmania major because of the various human diseases that this parasite is capable of causing. If infected by a leishmania parasite a number of diseases can form. Annually there are 2 million cases in 88 tropical and subtropical countries.
- How it infects:
- Parasite transmitted by sand flies as proliferative promastigote
- Differentiate into nondividing forms before inoculation into vertebrate host
- In host macrophages, phagocytose metacyclics --> differentiate into amastigotes (proliferate in phagolysosome)
- Leads to host macrophage lysis and infection of other macrophages
- Outcome of infection depends on species, host immune system and host genetics
- Interesting to look at genome because of the unique mechanism of regulating transcription which is atypical for eukaryotes
- Leishmania major is considered an "Old World Leishmania" species, meaning it contains 36 chromosome pairs. There are approximately 30 Leishmania species who's gene order is highly conserved.
- Ways in which it differs:
- Organization of protein coding genes: long, strand-specific polycistronic clusters
- No transcription factors
- This article determined the genome sequence of Leishmania major on a chromosome by chromosome basis. Present the structure and content based on molecular processes such as:
- chromatin remodeling
- transcription
- RNA processing
- Translation
- posttranslational modification
- protein turnover
- Also discuss essential host parasite interface developmental processes
- Template:vkuehn
- Viktoria Kuehn
- Week 1 Assignment
- Class Journal 1
- Week 2 Assignment
- Class Journal 2
- Vkuehn Week 2
- Week 3 Assignment
- Class Journal 3
- Vkuehn Week 3
- Week 4 Assignment
- Class Journal 4
- Vkuehn Week 4
- Week 5 Assignment
- Vkuehn Week 5
- Ensembl Database
- Week 6 Assignment
- Class Journal 6
- Vkuehn Week 6
- Week 7 Assignment
- Class Journal 7
- Vkuehn Week 7
- Week 8 Assignment
- Class Journal 8
- Vkuehn Week 8
- Leishmania major
- Week 9 Assignment
- Class Journal 9
- Vkuehn Week 9
- Week 10 Assignment
- Class Journal 10
- Vkuehn Week 10
- Leishmania major
- Week 11 Assignment
- Vkuehn Week 11
- Leishmania major Genome Reference Article Presentation
- Vkuehn Week 12
- Week 12 Assignment
- Leishmania major Week 12 Status Report
- Vkuehn Week 13
- Week 13 Assignment
- Vkuehn Week 15
- Week 15 Assignment
- Vkuehn Individual Assessment and Reflection
