Streptococcus pneumoniae

Group Deliverables

Team Journal Club Presentation

GenMAPP Gene Database: Media:Streptococcus_pneumoniae_TIGR4_20131125.gdb
ReadMe file (PDF):
- Sample ReadMe in Word format: ReadMe_Vc-Std_External_20131122.zip
- Include Gene Database Schema diagram in ReadMe
  - Sample schema in Adobe Illustrator format: Vibrio_schema_20101022.zip
Gene Database Testing Report (print from wiki to .pdf file):
Processed and analyzed DNA microarray dataset (.xls):
GenMAPP Expression Dataset file (.gex):
Filtered MAPPFinder Results (.xls):
Sample MAPP file of a relevant biological pathway for your species (.mapp):
Group Report describing the creation of the Gene Database and the biological analysis of the data (.doc or .pdf)

PowerPoint presentation (.ppt, given on Thursday, December 12)

Papers

Genome Paper

Title: Genome of the Bacterium Streptococcus pneumoniae Strain R6

By Hoskins et al. (2001)

Web link

PDF

Reference: Hoskins, J., Alborn, W.E. Jr., Arnold, J., Blaszczak, L.C., Burgett, S., Bradley, S., DeHoff, S.T., Estrem, L.F., Fu, D.J., Fuller, W., Geringer, C., Gilmour, R., Glass, J.S., Khoja1, H., Kraft, A.R., Lagace, R.E., LeBlanc, D.J., Lee, L.N., Lefkowitz, E.J., Lu, J., Matsushima, P., McAhren, S.M., McHenney, M., McLeaster, K., Mundy, C.W., Nicas, T.I., Norris, F.H., O'Gara1, M.J., Peery, R.B., Robertson, G.T., Rockey, P., Sun, P.M., Winkler, M.E., Yang, Y., Young-Bellido, M., Zhao, G., Zook, C.A., Baltz, R.H., Jaskunas, S.R., Rosteck Jr., P.R., Skatrud, P.L., and Glass, J.I. (2001) Genome of the bacterium Streptococcus pneumoniae strain R6. Journal of Bacteriology 183(19): 5709-5717. doi: 10.1128/JB.183.19.5709-5717.2001

Microarray Paper

Sanchez et. al. 2011

Streptococcus pneumoniae in Biofilms Are Unable to Cause Invasive Disease Due to Altered Virulence Determinant Production

Web Link: Biofilm paper

PDF: Media:Biofilms_paper.pdf

Data at: GEO link and Array Express link

Experiments Performed: Examined genes related to biofilm formation of Streptococcus pneumoniae

Replicates: 3 biological replicates, 3+ technical replicates

Reference: Sanchez, C.J., Kumar, N., Lizcano, A., Shivshankar, P., Dunning Hotopp, J.C., Jorgensen, J.H., Tettelin, H., and Orihuela, C.J. (2011) Streptococcus pneumoniae in Biofilms Are Unable to Cause Invasive Disease Due to Altered Virulence Determinant Production. PLoS ONE 6(12): e28738. doi:10.1371/journal.pone.0028738

Found by Kevin